Amoss Sign is positive in which conditions?

• A. Ankylosing spondylitis
• B. Severe sprain or IVD syndrome
• C. Carpal tunnel syndrome
• D. Migraine

Answer: (B)

Amoss sign is a provocative spinal test that helps identify axial spine pathology by producing or worsening pain when the spine is stressed, such as with movements or pressures that irritate injured spinal structures. It’s most consistent with acute mechanical problems like a severe sprain or intervertebral disc syndrome, where irritated ligaments, joints, or disc material press on nerve roots and pain is reproduced. In conditions like ankylosing spondylitis, the pain is inflammatory and not specifically activated by this maneuver; in carpal tunnel syndrome the issue is at the wrist and involves the median nerve, not the spine; and migraine involves intracranial vascular/neuronal processes, not spinal pathology. Therefore a positive Amoss sign points to acute spinal/axial pathology, such as severe sprain or IVD syndrome.